Assessment of Urinary Neutrophil Gelatinase-Associated Lipocalin to Predict Acute Kidney Injury in Children Research Multiple Nephrotoxic Medications
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 134
- 试验地点
- 2
- 主要终点
- Number of Patients With Nephrotoxic Medication Associated AKI Detected by Urinary NGAL
研究概览
简要总结
Nephrotoxic medication (NTMx) exposure is one of the most commonly cited causes of acute kidney injury (AKI) in hospitalized children, and is the primary cause of AKI in 16% of cases. Through initial work at Cincinnati Children's Medical Center, NTMx exposure was found to be potentially modifiable and the associated AKI is an avoidable adverse safety event. Currently, only serum Creatinine monitoring is available to monitor for NTMx-associated AKI. The hypotheses of this NINJA NGAL study are that (1) urine NGAL is highly sensitive to detect NTMx-associated AKI, and (2) Bedside test of urine from high risk NTMx-exposed patients are adequate and reliable compared to urine NGAL measured from the clinical platform.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving 3 or more nephrotoxic medications on the same day OR
- •Receiving 3 or more days of an intravenous aminoglycoside or vancomycin
排除标准
- •Currently being treated for a urinary tract infection
- •Presence of an acute kidney injury prior to enrollment
结局指标
主要结局
Number of Patients With Nephrotoxic Medication Associated AKI Detected by Urinary NGAL
时间窗: 9 Days
AKI, defined as a 50% rise in serum Creatinine over baseline or a 0.3 mg/dL rise within 48 hours, will be first detected by a rise in Urinary NGAL
次要结局
- Point of Care NGAL Reliability Compared to Clinical Urinary NGAL(7 Days)