The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients

Withdrawn

• Conditions: Ureteropelvic Junction Obstruction

• Registration Number: NCT01711996
• Lead Sponsor: Yonsei University

Brief Summary

Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of hydronephrosis in pediatric ureteropelvic junction obstruction (UPJO) patients. We are trying to analyze whether it is related with the grade of renal injury in UPJO patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Primary Completion: 2012-08
• Study First Submitted: 2012-10-17
• Study First Submitted QC: 2012-10-22
• Study First Posted: 2012-10-23
• Study Completion: 2013-08
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-03
• Last Update Posted: 2021-05-06

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

<Group 1>

1. 0-3 year old patients with SFU grade 2 or more hydronephrosis without ureteral dilatation

2. needs pyeloplasty due to differential renal function (DRF)<40%, decreased DRF by more than 5%, development of urinary tract infection, development of urinary stone, and development of pain related with UPJO <Group 2>

3. 0-3 year old patients with SFU grade 3 or 4 hydronephrosis without ureteral dilatation 2. doesn't meet the above criteria for the indication of pyeloplasty <Group 3>

4. 0-3 year old children without any abnormality of urinary tract

Exclusion Criteria

<Group 1>

1. patients with contralateral disease affecting DRF

2. history of previous urinary tract surgery

3. follow up loss before diuretic renogram performed at 6-12 months from operation <Group 2, 3>

4. patients with contralateral disease affecting DRF 2. history of previous urinary tract surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The level of urinary NGAL and the degree of renal injury	6 month after operation	Analysis of correlation between the level of urinary NGAL and the degree of renal injury

Trial Locations

Locations (1)

Department of Urology, Urological Science Institute, Yonsei University, Colleage of Medicine; 🇰🇷 Seoul, Korea, Republic of