Hyperbaric oxygen treatment in humans with Gram Positive Cocci endocarditis

Rigshospitalet - University Hospital of Copenhagen0 个研究点目标入组 10 人开始时间: 2019年3月14日最近更新: 2019年12月10日

适应症

试验速览

暂无简介。

•1)Left sided IE with gram positive cocci.
•2)IE has been diagnosed according to modified Duke Criteria.
•3)Patients must be stable, by means of no need for hemodynamic pressure support.
•4)The patient must be able to be seated for the 1.5 hour the HBOT at least two times a day for 3 days.
•5)The patient must be able to perform Valsalva’s – or Frenzels manoeuvre – to equalize middle ear pressure. As prophylaxis, all patients will receive detumescent nose drops as Otrivin® to facilitate ear- and sinuses equilibration. In the rare event it is still not possible for the patient to equalize pressure, a paracentesis or drainage of the tympanic membrane must be performed by the ENT doctor. All according to daily practice.
•6)The upstart of HBOT must be within the first week of relevant antibiotic IE therapy.
•7)If a central venous catheter has been inserted, a chest X-ray must confirm no suspicion of pneumothorax.
•8)Patients must be >18-years old.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 7
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 3

发起方

Rigshospitalet - University Hospital of Copenhagen