Protein-bound uraemic toxins in Peritoneal Dialysis Patients

Not Applicable

Withdrawn

• Conditions: Kidney Failure; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12613001250729
• Lead Sponsor: John Collins

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-11-13
• Last Update Posted: 17 August 2021

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients on Peritoneal Dialysis

Exclusion Criteria

Peritonitis within 1 month
Excessive co-morbidity

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The degree of protein binding for each of the measured solutes is established by measuring total solute in the PD effluent and then separating protein from the PD effluent and measuring the remaining free level. The difference is the bound solute which is expressed as a percentage of the total<br>[At baseline and 1 month later]

Secondary Outcome Measures

Name	Time	Method
Bovine Serum albumin is added to the PD effluent at a range of concentrations likely to be achievable with wearable sorbent-based recycling PD. Total,bound and free solutes are measured.This enables the development of a binding curve related to protein concentrations[At baseline and 1 month later]