Is Cognitive Rehabilitation Effective in Improving Cognition and Quality of Life of Patients with Chemotherapy-Related Cognitive Issues

Phase 1

• Conditions: Health Condition 1: D499- Neoplasm of unspecified behavior of unspecified site

• Registration Number: CTRI/2024/04/065805
• Lead Sponsor: Ravi Nair Physiotherapy College

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1)Newly diagnosed patients with stages I to III cancers planning to receive a definitive number of platinum-based compounds chemotherapy.

2)Patients who are given Taxanes and Platinum-based compounds – Cisplastin, Carboplatin and Oxaliplatin

3)3) Patients having Grade I or II cognitive impairment according to National Cancer Institute –common toxicity criteria.

4)Planned to receive a minimum of 4 cycles of chemotherapy treatment with either of the chemotherapy agents (Platinum based compound)

5)Both Male and female aged grouped between 14-70 years.

6)Patients who are given drugs according to approval of national cancer board

Exclusion Criteria

1)Patients having Pre-existing cognitive impairment.

2)Patient having Traumatic Brain Injury.

3)Patients having a previous history of any psychological condition that could impair cognitive function.

4)Patients who did not perceive any chemotherapy cycle after cancer treatment.

5)Patients with a previous history of cancer and chemotherapeutic drugs.

6)Those who were having any neurological disorders in the brain and spinal cord such as Alzheimer’s disease (AD), Lewy body disease, stroke (CVA), Huntington’s disease, MS, ALS, frontotemporal dementia, and vascular dementia; use of medication known to have a negative impact on cognition (benzodiazepines).

7)Use of antipsychotics and cholinesterase inhibitors (CHEIs); current or recent (past 6 months) alcohol or substance use disorder; any behavioural changes like depression, anxiety, stress, other systemic diseases likely to impair cognition, such as hypothyroidism, de ?ciency of folic acid or vitamin B12, or viral infection (syphilis, HIV); vision and speech impairment (aphasia).

Study & Design

• Study Type: Interventional
• Study Design: Not specified