Combination therapy in rheumatoid arthritis

Completed

• Conditions: Rheumatoid arthritis; Musculoskeletal Diseases; Other rheumatoid arthritis

• Registration Number: ISRCTN18445519
• Lead Sponsor: Turku University Hospital (Finland)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 199

Inclusion Criteria

1. American Rheumatism Association criteria for rheumatoid arthritis
2. Aged between 18 and 65 years, either sex
3. Duration of symptoms of less than 2 years
4. Active disease with three or more swollen joints and at least three of the following:
4.1. Erythrocyte sedimentation rate (ESR) at least 28 mm/h
4.2. C-reactive protein (CRP) above 19 mg/l
4.3. Morning stiffness of 29 minutes or more
4.4. More than five swollen joints
4.5. More than ten tender joints

Exclusion Criteria

1. Patients who had used DMARDs in the past
2. Had undergone glucocorticoid therapy within the previous 2 weeks
3. Patients with serious comorbidity
4. Suspected inability to comply with the protocol
5. Hypersensitivity to any study medication
6. A history of cancer
7. Pregnant women
8. Women of childbearing age who were not using reliable methods of contraception

Study & Design

• Study Type: Interventional
• Study Design: Not specified