NL-OMON52988已完成不适用
Volatile organic compounds as a biomarker in immune-mediated pulmonary arterial hypertension - Volatile organic compounds and pulmonary arterial hypertension
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 150 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1) PAH-CTD patients, inclusion criteria:
- •- classification as definite systemic sclerosis or systemic lupus erythematosus
- •according to respectively the ACR-EULAR criteria and SLICC criteria
- •- minimal age of 18 year
- •- diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
- •pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
- •catherization. , 2) IPAH patients, inclusion criteria:
- •- diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
- •pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
- •catherization.
- •- no family history of PAH
- •- triggering factor is excluded: connective tissue disease, drugs or toxins,
- •human immunodeficiency virus, congenital heart disease, portal hypertension,
- •schistosomiasis
- •- minimal age of 18 year, 3) SSc and SLE patients without PAH, inclusion
- •- classification as definite systemic sclerosis or systemic lupus erythematosus
- •according to respectively the ACR-EULAR criteria (16) and SLICC criteria (17)
- •- minimal age of 18 year
- •- no signs of PAH at screening visit
- •4) CTEPH patients, inclusion criteria:
- •- diagnosis of pulmonary hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg measured
- •by right heart catherization.
- •- mismatched perfusion defects on V/Q lung scan
排除标准
- •- active or treated malignancy
- •- tuberculosis or hepatitis B/C infection in case of immunosuppressive
- •- need to start immediately with immunosuppressive therapy
- •- already use of immune suppression
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