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临床试验/NL-OMON52988
NL-OMON52988已完成不适用

Volatile organic compounds as a biomarker in immune-mediated pulmonary arterial hypertension - Volatile organic compounds and pulmonary arterial hypertension

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 150 人开始时间: 待定最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
150

研究概览

简要总结

暂无简介。

研究设计

研究类型
Observational

入排标准

年龄范围
18 至 99(—)

入选标准

  • 1) PAH-CTD patients, inclusion criteria:
  • - classification as definite systemic sclerosis or systemic lupus erythematosus
  • according to respectively the ACR-EULAR criteria and SLICC criteria
  • - minimal age of 18 year
  • - diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
  • (mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
  • pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
  • catherization. , 2) IPAH patients, inclusion criteria:
  • - diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
  • (mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
  • pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
  • catherization.
  • - no family history of PAH
  • - triggering factor is excluded: connective tissue disease, drugs or toxins,
  • human immunodeficiency virus, congenital heart disease, portal hypertension,
  • schistosomiasis
  • - minimal age of 18 year, 3) SSc and SLE patients without PAH, inclusion
  • - classification as definite systemic sclerosis or systemic lupus erythematosus
  • according to respectively the ACR-EULAR criteria (16) and SLICC criteria (17)
  • - minimal age of 18 year
  • - no signs of PAH at screening visit
  • 4) CTEPH patients, inclusion criteria:
  • - diagnosis of pulmonary hypertension: mean pulmonary artery pressure
  • (mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg measured
  • by right heart catherization.
  • - mismatched perfusion defects on V/Q lung scan

排除标准

  • - active or treated malignancy
  • - tuberculosis or hepatitis B/C infection in case of immunosuppressive
  • - need to start immediately with immunosuppressive therapy
  • - already use of immune suppression

研究者

发起方
Medisch Universitair Ziekenhuis Maastricht

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