NL-OMON52988CompletedNot Applicable
Volatile organic compounds as a biomarker in immune-mediated pulmonary arterial hypertension - Volatile organic compounds and pulmonary arterial hypertension
Medisch Universitair Ziekenhuis Maastricht0 sites150 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 150
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •1) PAH-CTD patients, inclusion criteria:
- •- classification as definite systemic sclerosis or systemic lupus erythematosus
- •according to respectively the ACR-EULAR criteria and SLICC criteria
- •- minimal age of 18 year
- •- diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
- •pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
- •catherization. , 2) IPAH patients, inclusion criteria:
- •- diagnosis of pulmonary arterial hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg, and a
- •pulmonary vascular resistance (PVR) >=240 dynes.s.cm-5 measured by right heart
- •catherization.
- •- no family history of PAH
- •- triggering factor is excluded: connective tissue disease, drugs or toxins,
- •human immunodeficiency virus, congenital heart disease, portal hypertension,
- •schistosomiasis
- •- minimal age of 18 year, 3) SSc and SLE patients without PAH, inclusion
- •- classification as definite systemic sclerosis or systemic lupus erythematosus
- •according to respectively the ACR-EULAR criteria (16) and SLICC criteria (17)
- •- minimal age of 18 year
- •- no signs of PAH at screening visit
- •4) CTEPH patients, inclusion criteria:
- •- diagnosis of pulmonary hypertension: mean pulmonary artery pressure
- •(mPAP) of >=25 mmHg, pulmonary capillary wedge pressure (PCWP) <=15 mmHg measured
- •by right heart catherization.
- •- mismatched perfusion defects on V/Q lung scan
Exclusion Criteria
- •- active or treated malignancy
- •- tuberculosis or hepatitis B/C infection in case of immunosuppressive
- •- need to start immediately with immunosuppressive therapy
- •- already use of immune suppression
Investigators
Similar Trials
Unknown
Not Applicable
Analysis of Volatile Organic Compounds in the Exhaled Air in Inflammatory Bowel DiseaseVolatile Organic CompoundsInflammatory Bowel DiseaseNCT03414580Keimyung University Dongsan Medical Center90
Unknown
Not Applicable
Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH)Systemic LupusPulmonary Arterial HypertensionSystemic SclerosisNCT03819777Maastricht University Medical Center150
Withdrawn
Not Applicable
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in EthiopiaMalariaNCT02793414Menzies School of Health Research
Not yet recruiting
Not Applicable
Identification of specific volatile organic compound (VOCs) in exhaled breath to distinguish pancreatic ductal adenocarcinoma, pancreatic cystic neoplasm and patients without pancreatic-lesioPancreatic ductal adenocarcinomaIntraductal Papillary Mucinous NeoplasmVolatile organic compoundExhaled breathPancreatic adenocarcinomaIntraductal papillary mucinous neoplasm ,IPMNVolatile organic compoundExhaled breath- Alveolar airTCTR20211109002The Ratchadapisek Sompoch Endowment Fund144
Unknown
Not Applicable
Breath Analysis by Ion Mobility SpectrometryLung DiseasesNCT00632307Lung Clinic Hemer1,000
