Comparison of two proton pump inhibitor therapy approaches for laryngopharyngeal reflux disease treatment
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0004871
- Lead Sponsor
- Hallym University Medical Center-Dongtan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 72
(1) Patients over 18 year
(2) Those with above 13 and 7 score in reflux symptom index and reflux finding score and have laryngopharyngeal reflux disease in larynx endoscope
(3) Patients who agree to participate in this study voluntarily
(1) The highly sensitive person to proton pump inhibitor
(2) Those with the malignant tumor or infection of the larynx
(3) Those with need to take steroids or aspirin (more than 325mg/d), warfarin, coumarin during this study constantly
(4) Those who has undergone surgery or treatment for gastroesophageal reflux disease
(5) Those who has undergone gastric acid suppression surgery or gastro-duodenal surgery
(6) Those who has undergone major surgery affecting gastric acid secretion
(7) Those with the history of administration with other proton pump inhibitor or H2-blocker within 3 months
(8) Psychiatric patient, alcohol addictor or those with the history of drug abuse
(9) Pregnant and lactating women
(10) Childbearing women (Menopausal women who are amenorrheic for at least 12 months are considered to be non-childbearing women.)
(11) Those who participated in other clinical trial within 6 months before screening
(12) Those who are judged to be improper for this clinical trial
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reflux symptom index;Reflux finding score
- Secondary Outcome Measures
Name Time Method Hospital anxiety and depression (HAD)