Refractive and Biometric Outcomes in Patients With Retinopathy of Prematurity Treated With Intravitreal Injection of Ranibizumab as Compared With Bevacizumab - a Clinical Study of Correction at Three Years of Age
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 主要终点
- spherical equivalent
研究概览
简要总结
The investigators compared long-term refractive and biometric outcomes in children with retinopathy of prematurity who received two different anti-vascular endothelial growth factor agents.
详细描述
Purpose:
To compare refractive and biometric outcomes in patients with type 1 retinopathy of prematurity (ROP) treated with intravitreal injection of Ranibizumab (IVR), versus bevacizumab (IVB), at a corrected age of 3 years.
Methods:
A retrospective case series compared cycloplegic refractive statuses and biometric statuses in patients who received either IVR or IVB for Type 1 ROP, from April 2011 to April 2014.
Comparison of refractive errors and biometric findings between the two groups was performmed and multivariate analysis of possible factors contributive to visual acuity was also performmed
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 3 Years 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children with type 1 retinopathy of prematurity
- •children received anti-vascular endothelial growth factors (bevacizumab or ranibizumab)
排除标准
- •children withour retinopathy of prematurity
- •children with retinopathy of prematurity received laser therapy
研究组 & 干预措施
ROP group
children with retinopathy of prematurity received either bevacizumab or ranibizumab
干预措施: Bevacizumab (Drug)
ROP group
children with retinopathy of prematurity received either bevacizumab or ranibizumab
干预措施: Ranibizumab (Drug)
结局指标
主要结局
spherical equivalent
时间窗: at corrected age of 3 year-old
spherical power + half of cylinder power
astigmatism
时间窗: at corrected age of 3 year-old
in cylinder power
次要结局
- axial length(at corrected age of 3 year-old)
- lens thickness(at corrected age of 3 year-old)
- cornea radius(at corrected age of 3 year-old)
- anterior chamber depth(at corrected age of 3 year-old)
研究者
San Ni Chen
medical doctor
Changhua Christian Hospital