Imaging Epidemiological Investigation of Intracranial Aneurysms and the Prospective Study of Risk Factors:Assessment of MR Imaging Trail
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 4,000
- 试验地点
- 1
- 主要终点
- Intracranial aneurysms identified by CE-MRA
研究概览
简要总结
This is a prospective observational registry with intent to detect the prevalence of intracranial aneurysms with contrast-enhanced MR angiography (CE-MRA) at 1.5T, and to determine the risk factors such as high blood pressure and cigarette smoking relating to intracranial aneurysms.
详细描述
Intracranial aneurysms are common and have been reported increased incidence rate because of the widespread use of high-resolution imaging techniques. They are clinically important because of the life-threatening rupture and hemorrhage. Early detection and diagnosis is the key of treatment. Contrast-enhanced MR angiography (CE-MRA), as a simple, sensitivity and noninvasive method, is playing an important role in Vascular Imaging. CE-MRA has been an accuracy modality for intracranial aneurysm at most centers and proved the high sensitivity and accuracy comparing with DSA. Therefore, we use CE-MRA at 1.5T as a tool of epidemiological investigation of intracranial aneurysms.
In retrospective analysis, conventional risk factors for intracranial aneurysms include hypertension, hyperlipidemia, diabetes mellitus (DM), smoking history, and family history, etc. However, retrospective analysis probably gives an underestimation or overestimation of the actual results. Prospective analysis will get accurate data on the risk factors relating to intracranial aneurysms
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 20 to 80 years
- •Willing to undergo study procedures
- •Who are fully informed about the study and have signed the informed consent form
排除标准
- •History of intracranial aneurysm
- •History of intracranial tumor
- •History of cerebral infarction
- •Acute stroke
- •Require emergency treatment
- •Contraindication for MRI examination
- •Severely impaired renal functions
- •Known anaphylactic reaction to MR contrast media
- •Pregnancy or nursing
结局指标
主要结局
Intracranial aneurysms identified by CE-MRA
时间窗: 24 months
次要结局
- Statistical analysis of the prospective factors which contribute to the development of intracranial aneurysms(6 months after the study)
