Comparison of Extubation success between prophylactic Helmet NIV and High-flow Nasal Cannula in high risk of reintubation in post-extubation patients; A Randomized Controlled Trial

ational Research Council of Thailand(NRCT)0 个研究点目标入组 34 人开始时间: 2024年3月22日最近更新: 2024年8月19日

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•Patients aged > 18 years who consent to participate in the research project, with complete decision-making capacity, intubated for at least 48 hours in the intensive care unit or general ward of Chulalongkorn Hospital,Patients who have been assessed for readiness to wean from mechanical ventilation using the Spontaneous Breathing Trial (SBT) method, high risk of reintubation within 48 hours, Patients without or with minimal risk of aspiration.

•Patients previously treated with continuous positive airway pressure (CPAP), Patients with contraindications for positive pressure devices such as helmet non-invasive ventilation (NIV) and high-flow nasal cannula (HFNC), including:Cardiac or respiratory arrest, unstable vital signs, defined as systolic blood pressure < 90 mmHg and mean arterial pressure > 65 mmHg requiring vasopressor therapy, Failure of major organ systems, Upper airway obstruction or inability to clear secretions, Previous facial, nasal, or upper airway surgery, Claustrophobia, Patients diagnosed with neuromuscular junction disease or HIV, Mentally ill patients, Cancer patients or those in terminal illness, Patients with traumatic brain injury leading to intubation, Patients who have self-extubated, Patients expressing a desire not to be reintubated after extubation, Pregnant patients, Tracheostomized patients, Patients with elevated carbon dioxide levels during Spontaneous Breathing Trial (SBT) testing.

发起方

ational Research Council of Thailand(NRCT)