Search for antiviral antibodies in COVID-19 patients' eye secretions
Not Applicable
Completed
- Conditions
- COVID-19 (SARS-CoV-2 infection)Infections and Infestations
- Registration Number
- ISRCTN17301812
- Lead Sponsor
- niversity of Ferrara
- Brief Summary
2020 results in https://pubmed.ncbi.nlm.nih.gov/33153065/ (added 19/03/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
COVID-19 patient hospitalized at the University-Hospital of Ferrara (Italy)
Exclusion Criteria
Affected by specific ocular pathologies of infectious or other origin
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence and titer of anti-SARS-CoV-2 IgA in ocular fluid collected by Schirmer test at a single time point
- Secondary Outcome Measures
Name Time Method <br> 1. Presence of SARS-CoV-2 RNA genome in ocular fluid collected by Schirmer test at a single time point<br> 2. Presence and concentration of pro-inflammatory cytokines associated with the COVID-19 cytokine storm in ocular fluid collected by Schirmer test at a single time point<br> 3. Antibody response against the virus at the blood level (IgG and IgM) measured by a blood test at a single time point<br> 4. Ocular and respiratory symptoms recorded by the investigator at a single time point<br>