Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients
- Conditions
- STEMIThyroidCardiac Remodeling, Ventricular
- Interventions
- Other: Thyroid hormone levels
- Registration Number
- NCT03933358
- Lead Sponsor
- Beijing Friendship Hospital
- Brief Summary
This study aims to determine whether thyroid hormone levels are predictive of cardiac remodeling following myocardial infarction and the prognosis in patients with STEMI receiving primary percutaneous coronary intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 250
Inclusion Criteria
- with a confirmed STEMI diagnosis
- undergoing primary percutaneous coronary intervention (presenting <12h after symptom onset)
- patients agreed and provided informed consent
Exclusion Criteria
- past history of myocardial infarction or percutaneous coronary intervention or coronary artery bypass graft
- past history of heart failure (LVEF<40%) or myocardiopathy or atrial fibrillation
- past history of thyroid diseases, or were treated with amiodarone, dopamine, or corticosteroids before hospital admission
- contraindicating to cardiac magnetic resonance imaging
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Low T3 Thyroid hormone levels low triiodothyronine syndrome Euthyroid Thyroid hormone levels -
- Primary Outcome Measures
Name Time Method MACE (major adverse cardiovascular events) 12 months cardiovascular death, re-infarction, revascularization, and stroke
- Secondary Outcome Measures
Name Time Method all-cause death 12 months death caused by all reason
adverse cardiac remodeling 6 months a cut-off value of 12% change in left ventricular end-diastolic volume between the acute and follow-up magnetic resonance scans
Trial Locations
- Locations (1)
Beijing Friendship Hospital, Capital Medical University
🇨🇳Beijing, China