Copeptin in the Diagnosis and Differential Diagnosis of Diabetes Insipidus. The CoSIP-Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Diagnosis of diabetes insipidus(DI) centralis versus psychogenic DI
研究概览
简要总结
Evaluation of Copeptin in the differential diagnosis of diabetes insipidus.
详细描述
Background:
Plasma arginine vasopressin (AVP) measurement is recommended for the differential diagnosis of diabetes insipidus and polydipsia. However, AVP measurement is cumbersome. AVP is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of AVP. Copeptin can be assayed readily in plasma.
Aim: To evaluate the diagnostic accuracy of copeptin levels in the diagnosis and differential diagnosis of diabetes insipidus.
Design: Prospective, observational multicenter study.
Setting: Department of Endocrinology, University Hospital of Basel
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients > 18 years who are tested for the diagnosis of DI because of a history of polyuria (> 40 ml/kg per 24 hours) in the presence of polydipsia Patients with known DI will be contacted whether they agree to participate in the study and to undergo again a water deprivation test to measure copeptin to confirm the diagnosis.
排除标准
- •Polyuria of other origin, i.e. prostate hyperplasia, diabetes mellitus.
- •Pregnancy
- •The investigators do not perform the water deprivation test in patients with: *renal insufficiency
- •uncontrolled diabetes mellitus
- •hypovolemia of any cause
- •uncorrected deficiency of adrenal or thyroid hormones
- •No informed consent
结局指标
主要结局
Diagnosis of diabetes insipidus(DI) centralis versus psychogenic DI
时间窗: 2 years
次要结局
未报告次要终点