Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Pattern of brain metabolism using positron emission tomography(PET).
研究概览
简要总结
Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.
详细描述
Specific aims of the study include:
- To determine the pattern of brain metabolism using positron emission tomography (PET) found in chronic migraine, episodic migraine and control patients.
- To determine changes of resting state brain networks using magnetic resonance imaging (MRI) between patients with chronic or episodic headache and healthy volunteers.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged 18-65
- •No medical contraindication.
- •Chronic headache group:
- •Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations.
- •Able to provide informed consent.
- •Not pregnant or planning to become so, with a pregnancy test prior to scanning.
- •Control group and Episodic migraine group:
- •Patients with episodic migraine
- •Able to provide informed consent.
- •Not pregnant or planning to become so, with a pregnancy test prior to scanning.
排除标准
- •Taking a migraine preventive currently or in the last fifteen days.
- •Known claustrophobia
- •Patient is pregnant, planning to be pregnant, or becomes pregnant.
- •Patients with metal implants.
- •Patients who have had a study involving radiation within the one year prior to enrolling in this study
结局指标
主要结局
Pattern of brain metabolism using positron emission tomography(PET).
时间窗: Estimated to be approximately three years post baseline
Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging to determine the pattern of brain metabolism.
Changes of resting state brain networks using magnetic resonance imaging (MRI)
时间窗: Estimated to be approximately three years post baseline
Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging (MRI) To determine any changes of resting state brain networks
次要结局
未报告次要终点