Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Completed

• Conditions: Chronic Migraine; Migraine

• Registration Number: NCT01741246
• Lead Sponsor: University of California, San Francisco

Brief Summary

Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.

Detailed Description

Specific aims of the study include:

1. To determine the pattern of brain metabolism using positron emission tomography (PET) found in chronic migraine, episodic migraine and control patients.

2. To determine changes of resting state brain networks using magnetic resonance imaging (MRI) between patients with chronic or episodic headache and healthy volunteers.

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2012-11-26
• Study First Submitted QC: 2012-11-30
• Study First Posted: 2012-12-04
• Status Verified: 2015-06
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Last Update Submitted: 2015-06-26
• Last Update Posted: 2015-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

• Patients aged 18-65

  • No medical contraindication.

Chronic headache group:

• Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations.
• Able to provide informed consent.
• Not pregnant or planning to become so, with a pregnancy test prior to scanning.

Control group and Episodic migraine group:

• Patients with episodic migraine
• Able to provide informed consent.
• Not pregnant or planning to become so, with a pregnancy test prior to scanning.

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Exclusion Criteria

• Taking a migraine preventive currently or in the last fifteen days.
• Known claustrophobia
• Patient is pregnant, planning to be pregnant, or becomes pregnant.
• Patients with metal implants.
• Patients who have had a study involving radiation within the one year prior to enrolling in this study

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pattern of brain metabolism using positron emission tomography(PET).	Estimated to be approximately three years post baseline	Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging to determine the pattern of brain metabolism.
Changes of resting state brain networks using magnetic resonance imaging (MRI)	Estimated to be approximately three years post baseline	Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging (MRI) To determine any changes of resting state brain networks

Trial Locations

Locations (1)

UCSF; 🇺🇸 San Francisco, California, United States