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临床试验/NCT04536389
NCT04536389Unknown不适用

Pregnancy Rates in Women With Normal Uterine Cavity With and Without Cervical Abnormalities

Assiut University1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2018年10月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
120
试验地点
1
主要终点
clinical pregnancy rate

研究概览

简要总结

The aim of our study is to investigate the pregnancy rates in women with normal uterine cavity ,with and without cervical abnormalities.

详细描述

The cervix is made up of the ectocervix and endocervix and is on average 3-4 cm long and 2.5 cm wide (Pardo et al., 2003; Mazouni et al., 2005; Robert et al., 2013). The ectocervix is the portion of the cervix projecting into the vagina. It is composed of non-keratinized stratified squamous epithelium and is divided into anterior and posterior lips. The squamocolumnar junction is the area where the epithelial cells of the endocervix and ectocervix meet (Herfs et al., 2013). In this area, the columnar cells of the endocervix undergo metaplasia to the squamous cells of the ectocervix. The opening of the ectocervix to the vagina is called the external os. Although studies of cervical length in non-pregnant women are few, it is acknowledged that the size and shape of both the cervix and the external os differ in women (Pardo et al., 2003; Mazouni et al., 2005) and vary with age, hormonal changes, parity and surgical treatments to the cervix.

Further evaluation of any cervical abnormalities by hysteroscopy eg. (choronic cervicitis , microcycstic epethelium ,micropolypi , cervical stenosis) before ICSI could address us to a hidden cause of infertility and may improve the pregnancy rates in ICSI cycles with prompt medical or surgical managment of such pathologies.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 38 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Women between 18 and 38 years old.
  • An indication for IVF/ICSI.
  • Women with primary or secondary infertility.
  • Women with BMI between 20 & 35.

排除标准

  • Refusal to join the study.
  • Untreated tubal hydrosalpinges.
  • Poor responders as assessed by AFC 4 or less, AMH O.8 ng/dl (nice 2013).

结局指标

主要结局

clinical pregnancy rate

时间窗: 7thweek of prgnancy for cardiac pulsations

clinical pregnancy rate will be described

次要结局

  • Abortion rate(up to 28 weeks)
  • chemical pregnancy rate(4 weeks)
  • preterm labour(9 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Momen Ahmed Mohammed Kamel

principle investigator

Assiut University

研究点 (1)

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