Pregnancy Rates in Women With Normal Uterine Cavity With and Without Cervical Abnormalities
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
The aim of our study is to investigate the pregnancy rates in women with normal uterine cavity ,with and without cervical abnormalities.
详细描述
The cervix is made up of the ectocervix and endocervix and is on average 3-4 cm long and 2.5 cm wide (Pardo et al., 2003; Mazouni et al., 2005; Robert et al., 2013). The ectocervix is the portion of the cervix projecting into the vagina. It is composed of non-keratinized stratified squamous epithelium and is divided into anterior and posterior lips. The squamocolumnar junction is the area where the epithelial cells of the endocervix and ectocervix meet (Herfs et al., 2013). In this area, the columnar cells of the endocervix undergo metaplasia to the squamous cells of the ectocervix. The opening of the ectocervix to the vagina is called the external os. Although studies of cervical length in non-pregnant women are few, it is acknowledged that the size and shape of both the cervix and the external os differ in women (Pardo et al., 2003; Mazouni et al., 2005) and vary with age, hormonal changes, parity and surgical treatments to the cervix.
Further evaluation of any cervical abnormalities by hysteroscopy eg. (choronic cervicitis , microcycstic epethelium ,micropolypi , cervical stenosis) before ICSI could address us to a hidden cause of infertility and may improve the pregnancy rates in ICSI cycles with prompt medical or surgical managment of such pathologies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 38 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women between 18 and 38 years old.
- •An indication for IVF/ICSI.
- •Women with primary or secondary infertility.
- •Women with BMI between 20 & 35.
排除标准
- •Refusal to join the study.
- •Untreated tubal hydrosalpinges.
- •Poor responders as assessed by AFC 4 or less, AMH O.8 ng/dl (nice 2013).
结局指标
主要结局
clinical pregnancy rate
时间窗: 7thweek of prgnancy for cardiac pulsations
clinical pregnancy rate will be described
次要结局
- Abortion rate(up to 28 weeks)
- chemical pregnancy rate(4 weeks)
- preterm labour(9 months)
研究者
Ahmed Momen Ahmed Mohammed Kamel
principle investigator
Assiut University
