Importance of Liver Innervation for the Osmopressor Response in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- norepinephrine plasma level
研究概览
简要总结
In patients with autonomic dysfunction water drinking elicits a pressor response mediated by sympathetic activation. If any, in healthy subjects there is only a slight increase in blood pressure. However, the sympathetic activation is observable by resting energy expenditure increases greater than 20%.
The investigators believe that the response to water may be mediated through sympathetic activation elicited by osmosensitve spinal afferents in the liver. Therefore, the investigators want to test water in liver transplant patients who have a denervated liver. Kidney transplant patients serve as control subjects. The investigators hypothesize that the increase in norepinephrine after water drinking is blunted in liver transplant recipients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •3 to 24 month past liver or kidney transplantation
- •age 18 to 60
- •written informed consent
- •ability to understand the oral and written information
排除标准
- •pregnancy or lactation
- •transplantation of another organ
- •chronic heart or vascular disease
- •known alcohol or drug abuse
- •psychiatric diseases (e.g. chronic depression, schizophrenia, drug addiction)
结局指标
主要结局
norepinephrine plasma level
时间窗: 30-40 minutes after water drinking
次要结局
- pressure response(blood pressure 30-40 minutes after water drinking)