Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Orthostatic Hypotension
- 发起方
- Satish R. Raj
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- blood pressure
- 状态
- 进行中（未招募）
- 最后更新
- 6个月前
概览
简要总结
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.
详细描述
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.
研究者
Satish R. Raj
Assistant Professor of Medicine & Pharmacology
Vanderbilt University Medical Center
入排标准
入选标准
- •orthostatic hypotension (fall in BP\>20/10 mmHg)
- •pressor response to water in other studies
- •Age 18-80 years
排除标准
- •pregnancy
结局指标
主要结局
blood pressure
时间窗: 2nd water intervention
次要结局
- heart rate(2nd intervention)