Oral Water Ingestion in Heart Transplant Patients
- Conditions
- Cardiac TransplantationBlood Pressure
- Registration Number
- NCT00581321
- Lead Sponsor
- Satish R. Raj
- Brief Summary
In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
- Detailed Description
In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 40
- s/p cardiac transplantation scheduled for clinical right heart catheterization
- age > 18 years
- significant tricuspid regurgitation
- inability to safely swallow 500 ml of water
- other major medical comorbidities such as advanced renal disease where water ingestion may be harmful to patient
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method change in total vascular resistance 40 min (before to 30 min after water ingestion
- Secondary Outcome Measures
Name Time Method heart rate 40 min blood pressure 40 min plasma norepinephrine 40 minutes
Trial Locations
- Locations (2)
Tennessee Valley Health Systems (Nashville VA)
🇺🇸Nashville, Tennessee, United States
Vanderbilt University
🇺🇸Nashville, Tennessee, United States
Tennessee Valley Health Systems (Nashville VA)🇺🇸Nashville, Tennessee, United States