Acute Hemodynamic Effects of Oral Water in a Stable Cardiac Transplant Population
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- change in total vascular resistance
研究概览
简要总结
In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
详细描述
In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •s/p cardiac transplantation scheduled for clinical right heart catheterization
- •age > 18 years
排除标准
- •significant tricuspid regurgitation
- •inability to safely swallow 500 ml of water
- •other major medical comorbidities such as advanced renal disease where water ingestion may be harmful to patient
结局指标
主要结局
change in total vascular resistance
时间窗: 40 min (before to 30 min after water ingestion
TPR measured by Modelflow
次要结局
- blood pressure(40 min)
- heart rate(40 min)
- plasma norepinephrine(40 minutes)
研究者
Satish R. Raj
Assistant Professor of Medicine & Cardiology
Vanderbilt University Medical Center