Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- effects on oxygenation, respiratory mechanics
研究概览
简要总结
The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics. The purpose of this study is to evaluate fluids effects on oxygenation, respiratory mechanics, by using two different solutions: crystalloid or colloid.
详细描述
Inclusion Criteria:
- patients undergoing elective abdominal, thoracic, vascular surgery
- minimum age 18 years
- informed consent
Exclusion Criteria:
- patients with severe cardiomyopathy or severe heart failure
- history of coagulation disorders
- patients with severe cardiovascular or respiratory disorders
- renal insufficiency
Respiratory mechanic parameters (i.e., inspiratory peak pressure, plateau pressure, total airway resistance, and static compliance) are obtained .Blood samples are drawn simultaneously from the arterial catheters for gas analysis. Data were collected after induction of anesthesia (T0) after 1 h (T1), 2 h (T2), 3 h (T3) and at the end of surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing elective abdominal, thoracic, vascular surgery
- •minimum age 18 years
- •informed consent
排除标准
- •patients with severe cardiomyopathy or severe heart failure
- •history of coagulation disorders
- •patients with severe cardiovascular or respiratory disorders
- •renal insufficiency
- •severe liver diseases
研究组 & 干预措施
Cristalloid
group cristalloid (ringer lactate)
干预措施: Cristalloid administration (Drug)
colloids
colloid: cristalloid in according to cardiac output
干预措施: Group Colloid (Drug)
结局指标
主要结局
effects on oxygenation, respiratory mechanics
时间窗: every 30 minutes till the end of surgery
Lung compliance (l/cmH20), Airaway resistance (cmH2O/L/sec) and PaO2 will be measured
次要结局
- Incidence of respiratory complications(28 days)
研究者
Savino Spadaro
Researcher
Università degli Studi di Ferrara