Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
Overview
- Phase
- Not Applicable
- Intervention
- Cristalloid administration
- Conditions
- Mechanical Ventilation Complication
- Sponsor
- Università degli Studi di Ferrara
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- effects on oxygenation, respiratory mechanics
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics. The purpose of this study is to evaluate fluids effects on oxygenation, respiratory mechanics, by using two different solutions: crystalloid or colloid.
Detailed Description
Inclusion Criteria: * patients undergoing elective abdominal, thoracic, vascular surgery * minimum age 18 years * informed consent Exclusion Criteria: * patients with severe cardiomyopathy or severe heart failure * history of coagulation disorders * patients with severe cardiovascular or respiratory disorders * renal insufficiency Respiratory mechanic parameters (i.e., inspiratory peak pressure, plateau pressure, total airway resistance, and static compliance) are obtained .Blood samples are drawn simultaneously from the arterial catheters for gas analysis. Data were collected after induction of anesthesia (T0) after 1 h (T1), 2 h (T2), 3 h (T3) and at the end of surgery. Primary outcome: evaluate the fluids effects on oxygenation, respiratory mechanics Secondary outcome: Incidence of surgery related complications
Investigators
Savino Spadaro
Researcher
Università degli Studi di Ferrara
Eligibility Criteria
Inclusion Criteria
- •patients undergoing elective abdominal, thoracic, vascular surgery
- •minimum age 18 years
- •informed consent
Exclusion Criteria
- •patients with severe cardiomyopathy or severe heart failure
- •history of coagulation disorders
- •patients with severe cardiovascular or respiratory disorders
- •renal insufficiency
- •severe liver diseases
Arms & Interventions
Cristalloid
group cristalloid (ringer lactate)
Intervention: Cristalloid administration
colloids
colloid: cristalloid in according to cardiac output
Intervention: Group Colloid
Outcomes
Primary Outcomes
effects on oxygenation, respiratory mechanics
Time Frame: every 30 minutes till the end of surgery
Lung compliance (l/cmH20), Airaway resistance (cmH2O/L/sec) and PaO2 will be measured
Secondary Outcomes
- Incidence of respiratory complications(28 days)