Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 2
- 主要终点
- number of fluid responders 30 minutes after fluid expansion
研究概览
简要总结
Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer subject between 18 and 30 years old
- •patient with a regular sinus rhythm
- •Echogenic subject.
- •Fasting of solid and liquid since 8 h
- •Subject in regular sinus rhythm.
- •Written consent signed.
排除标准
- •Any known cardiac, renal or endocrine pathology.
- •Arrhythmia rhythm disorder by atrial fibrillation
- •Pregnant or nursing woman.
- •Pathology versus indicating Nacl administration.
- •Person under tutors or curators or deprived of liberty.
- •Person not affiliated to a social security scheme.
结局指标
主要结局
number of fluid responders 30 minutes after fluid expansion
时间窗: 30 minutes after fluid expansion
次要结局
未报告次要终点