Biomarkers in Samples From Patients With B-Cell Acute Lymphoblastic Leukemia
Completed
- Conditions
- Leukemia
- Registration Number
- NCT01505699
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.
- Detailed Description
OBJECTIVES:
* To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo.
* To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups.
OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 186
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comprehensive view of microRNA expression by cytogenetic subgroup 1 year MicroRNA expression in relation to clinical outcome 1 year Differential microRNA expression between normal B-cells and progenitors compared to B-ALL 1 year
- Secondary Outcome Measures
Name Time Method