Effect of Two Exercise Programme on Gut Microbiota, Hepatic Metabolism and Adipokines in Sedentary Adults With Overweight
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Disturbance
- Sponsor
- Universidad Santo Tomas
- Locations
- 1
- Primary Endpoint
- Gut microbiota
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
This project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects of physical exercise on them. The aim of the research is to advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic/cardiometabolic health, as well as the application of differential proteomics technologies by means of Arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in Latin America.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sedentary males
- •BMI\>25 kg/m2, on a stable body weight for the last 3 months
Exclusion Criteria
- •Acute or chronic illness
- •Use of antibiotics the past 2 months
Outcomes
Primary Outcomes
Gut microbiota
Time Frame: Baseline, and 6 weeks immediately after the interventions ends
Change from Baseline in the gut microbiota composition measured by amplicon sequencing
Plasma metabolomic profile
Time Frame: Baseline, and 6 weeks immediately after the interventions ends
Change from Baseline in the metabolomic profile will be also evaluated by a HPLC-MS approach
Secondary Outcomes
- Plasma hepatokines(Baseline, and 6 weeks immediately after the interventions ends)
- Body composition(Baseline, and 6 weeks immediately after the interventions ends)
- Glucose(Baseline, and 6 weeks immediately after the interventions ends)
- Insulin(Baseline, and 6 weeks immediately after the interventions ends)
- Physical fitness(Baseline, and 6 weeks immediately after the interventions ends)
- Glycated hemoglobin(Baseline, and 6 weeks immediately after the interventions ends)
- Bioinflammatory blood markers(Baseline, and 6 weeks immediately after the interventions ends)
- Energy substrate oxidation(Baseline, and 6 weeks immediately after the interventions ends)
- Resting Metabolic Rate(Baseline, and 6 weeks immediately after the interventions ends)