To Evaluate Coronally Advanced Flap with Chorionic Membrane in Treatment of Isolated Gingival Recession: A Randomized Controlled Trail.

Completed

• Conditions: Gingivitis and periodontal diseases,

• Registration Number: CTRI/2022/09/045303
• Lead Sponsor: Dr Geddam Navya

Brief Summary

Gingival recession is the “apical migration of the gingival margin below the cemento-enamel junction (CEJ).†It is a multifactorial disease commonly caused by the accumulation of plaque biofilm resulting in inflammatory periodontal diseases and due to trauma caused by faulty and aggressive tooth brushing.  The coronally advanced flap (CAF) is a commonly used method for root coverage, and it has demonstrated very good results in treating gingival recessions regarding root coverage and esthetic outcomes. They possess antimicrobial and antibacterial properties and have shown to reduce inflammation and provide a protein-rich matrix, thereby facilitating the migration of cells at the defect area. Yadav K et al in 2015, concluded that, Chorionic membrane provides an effective alternative to autograft tissue in the treatment of shallow-to-moderate Miller’s Class I and II recession defects. In addition, the self adherent nature of the amniotic membrane significantly reduced surgical time and easier to perform. Chorion membrane has shown to reduce scar formation and inflammation, enhancing healing of the wound. Its matrix contains growth factors such as keratinocyte growth factor, basic fibroblast growth factor, and transforming growth factor-b, which help in regenerating the periodontium and gives a setting for faster healing.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-09
• Study Completion: 2023-02-08
• Last Update Posted: 2024-07-05

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Subjects who are diagnosed with Millers Class- I and Class-II gingival recession in anterior teeth and premolars, Subjects aged between 18-45 years of both sexes, Subjects who are willing to participate in the study.

Exclusion Criteria

Participants who had undergone any mucogingival procedures at the selected sites within the previous 3 months, Subjects with any known disease or intake of any medication that affects periodontal status, Molar teeth and teeth with poor periodontal prognosis, Subjects allergic to local anesthesia and chlorhexidine (CHX), antibiotic, and analgesic which would be prescribed, Subjects with Aggressive periodontitis, Current Smokers and Alcoholics, Pregnant or Lactating females, Subjects who are not willing to participate in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recession height,	At baseline and 6 months
Recession width,	At baseline and 6 months
Clinical attachment loss,	At baseline and 6 months
width of keratinized gingiva	At baseline and 6 months

Secondary Outcome Measures

Name	Time	Method
Gingival tissue thickness, Complete root coverage and Mean root coverage.	At baseline 1 month and 6 months

Trial Locations

Locations (1)

Sri Venkateshwaraa Dental College; 🇮🇳 Pondicherry, PONDICHERRY, India

Sri Venkateshwaraa Dental College

🇮🇳Pondicherry, PONDICHERRY, India

Dr Geddam Navya

Principal investigator

9390964123

geddamnavya1@gmail.com