Effect of blood derived membrane versus tissue harvested from palate in management of gum recession

Completed

• Conditions: Gingival recession,

• Registration Number: CTRI/2021/05/033726
• Lead Sponsor: Dr Anupama Tadepalli

Brief Summary

Gingival recession is described as apical migration of the free gingival margin relative to the cemento enamel junction leading to root exposure. The prevalence of mid-buccal recession defects was 91.6% as indicated in a recent epidemiological study conducted by NHANES 2020.Gingival recession is often associated with dentinal hypersensitivity, esthetic issues and also root caries. Periodontal plastic procedures aim to achieve complete root coverage while enhancing aesthetics by integrating mucosa and keratinized gingiva with adjacent tissues.

Periodontal wound healing is a complex biological mechanism where multiple cellular events occur concurrently leading to repair or regeneration.Platelets are the initial cells involved in the wound healing process. Upon activation, they release various bioactive molecules, cytokines, and adhesive proteins stimulating inflammatory cells to populate in the surgical area thereby setting the pace for the wound healing process.

A-PRF obtained by centrifugation protocol of 1500rpm for 14min at 200G, exhibited porous fibrin structure with larger interfibrinous space incorporating quantitatively more platelets and inflammatory cells, evenly distributed all through the matrix releasing significantly increased growth factor proteins (VEGF, PDGF, TGF-β, IGF and EGF). A-PRF was found to contain increased levels of VEGF, responsible for neoangiogenesis, monocytes as a source for BMP’s and fibronectin for extracellular matrix formation. The potential benefit of advanced platelet rich fibrin in management of gingival recession has not yet been established. The aim of this clinical study was to evaluate and compare the clinical efficacy of conventional gold standard connective tissue graft and A-PRF in the treatment of gingival recession defects.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-06
• Study Completion: 2023-01-18
• Last Update Posted: 2024-11-22

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1.Systematically healthy patients manifesting with millers class I and II recession defects in maxillary anteriors and premolars 2.
• Minimum recession height ≥ 2mm.

Exclusion Criteria

• Millers class III and 1V gingival recession 2.
• Recession sites with probing depth ≥ 4mm and mobile teeth 3.
• Teeth with prosthetic restoration 4.
• Anaemic patients 5.
• Pregnant and lactating women 7.
• Patients with poor oral hygiene 8.
• Systemic condition /disease/ any medication influencing the periodontal therapy and disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess and compare the changes in Recession height	Baseline, 3 months and 6 months

Secondary Outcome Measures

Name	Time	Method
To assess and compare the changes in gingival biotype	Baseline, 3 months and 6 months

Trial Locations

Locations (1)

SRM Dental College; 🇮🇳 Chennai, TAMIL NADU, India

SRM Dental College

🇮🇳Chennai, TAMIL NADU, India

Dr Anupama Tadepalli

Principal investigator

9677065517

anupamamds@gmail.com