Insulin Therapy in non-diabetic patients with Acute Coronary Syndromes: Effect of strict glycemic control on systemic endothelial function, coronary flow reserve, and left ventricular contractility - ITACAS
- Conditions
- Iperglycemia with Acute Coronary SyndromeMedDRA version: 9.1Level: LLTClassification code 10051592Term: Acute coronary syndrome
- Registration Number
- EUCTR2007-003906-89-IT
- Lead Sponsor
- Istituto Fisiologia Clinica, CNR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
symptoms of ischemia that were increasing or occurred at rest, with the last episode occurring no more than 24 hours before randomization; an elevated cardiac troponin T levels (>=0.03 mcg per liter); and either electrocardiographic evidence of ischemia on admission or a documented history of coronary artery disease
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
known diabetes at the admission, an age younger than 18 years or older than 80
years, myocardial infarction with ST-segment elevation in the past 48 hours, or inability to give
informed consent.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary end point(s): Endothelial function, coronary flow reserve.;Main Objective: assess in patients with acute coronary syndromes (ACS) the effects of strict (with intensive insulin therapy) vs. conventional therapy on endothelial function, coronary flow reserve and left ventricular contractility;Secondary Objective: ND
- Secondary Outcome Measures
Name Time Method