Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss
- Conditions
- Weight LossObesity
- Interventions
- Dietary Supplement: Weight loss group (Full meal replacement products)
- Registration Number
- NCT01780870
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Brief Summary
The main purpose of this study is to assess factors mediating the changes in insulin sensitivity and glucose tolerance before and after 10 lbs ± or 2% weight loss reduction as well as 2, 3, 6, 12, and 24 months after initiation of a low calorie diet.
The investigators will also study the following:
1. The impact of diet induced weight loss on hormones/adipokine levels
2. The impact of diet induced weight loss on leptin tolerance
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Weight loss group Weight loss group (Full meal replacement products) Full Meal replacement Protocol
- Primary Outcome Measures
Name Time Method The Primary Outcome Will be the Leptin Levels at Baseline and 8 Weeks 8 weeks The secondary outcome was deleted, since it was finally not performed in the study due to problems in enrollment
The Primary Outcome Will be Insulin Levels at Baseline and 8 Weeks 8 weeks The secondary outcome was deleted, since it was finally not performed in the study due to problems in enrollment
The Primary Outcome Will be HOMA-IR at Baseline and 8 Weeks 8 weeks The secondary outcome was deleted, since it was finally not performed in the study due to problems in enrollment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States