Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 试验地点
- 1
- 主要终点
- intracellular lipid content in liver and muscle
研究概览
简要总结
The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •written informed consent
- •must be of legal age and competent
- •Age > 18 years
- •presently diagnosed with hypothyroidism
排除标准
- •alcohol consumption >21 units per week
- •Malignant disease
- •pregnancy
- •magnetic implants or material in the body
- •BMI > 30
- •Heart disease (NYHA >2)
- •Uncontrolled hypertension
- •Manifest diabetes mellitus
- •Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
研究组 & 干预措施
1
the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism
干预措施: Levothyroxin (Drug)
结局指标
主要结局
intracellular lipid content in liver and muscle
时间窗: before and after 3 months treatment with growth hormone
intraabdominal lipid content
时间窗: before and after treatment
insulin sensitivity
时间窗: before and after treatment
substrate metabolism
时间窗: before and after treatment
intracellular signaling in the basal state and during insulin stimulation
时间窗: before and after treatment
次要结局
未报告次要终点