Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Not Applicable

Terminated

• Conditions: Hypothyroidism
• Interventions: Drug: Levothyroxin

• Registration Number: NCT00770016
• Lead Sponsor: University of Aarhus

Brief Summary

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-10-08
• Study First Submitted QC: 2008-10-08
• Study First Posted: 2008-10-09
• Study Start: 2010-01
• Primary Completion: 2010-01
• Status Verified: 2010-10
• Last Update Submitted: 2010-10-25
• Last Update Posted: 2010-10-26
• Study Completion: 2011-01

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• written informed consent
• must be of legal age and competent
• Age > 18 years
• presently diagnosed with hypothyroidism

Exclusion Criteria

• alcohol consumption >21 units per week
• Malignant disease
• pregnancy
• magnetic implants or material in the body
• BMI > 30
• Heart disease (NYHA >2)
• Uncontrolled hypertension
• Manifest diabetes mellitus
• Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Levothyroxin	the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism

Primary Outcome Measures

Name	Time	Method
intracellular lipid content in liver and muscle	before and after 3 months treatment with growth hormone
intraabdominal lipid content	before and after treatment
insulin sensitivity	before and after treatment
substrate metabolism	before and after treatment
intracellular signaling in the basal state and during insulin stimulation	before and after treatment

Trial Locations

Locations (1)

Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,; 🇩🇰 Aarhus, Denmark