Ramdomized non-inferiority clinical trial to evaluate the safety and efficacy of short duration therapy for non complicated enterococcal bacteremia. - INTENSE

Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla0 个研究点目标入组 284 人开始时间: 2024年4月26日最近更新: 2024年7月22日

适应症

试验速览

阶段: 1 期
状态: 进行中（未招募）
发起方: Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla
入组人数: 284

暂无简介。

•Adult patients (18 years or older) hospitalized with E. faecalis or E. faecium bacteremia., Negative control blood cultures performed between days 2-3 of treatment after the start of active treatment., Disappearance of fever (> 37.8ºC) in the first 72 hours., Signed informed consent

•Polymicrobial bacteremia., Patients with limited life expectancy in whom only conservative clinical management had been decided., Hemodynamic instability on day 5-6 after the start of active treatment., Patients wearing endovascular devices or heart valves prosthetics., Outbreak of uncontrolled bacteremia adequately defined as abscess not drained, bile duct infection associated with plastic prostheses not removed or not replaced within the first 72 hours of bacteremia, other infections related to unremoved prostheses, prostatitis, and endocarditis infectious, as well as infections that require prolonged treatment, such as joint and bone infections., Existence of a secondary focus, different from the initial focus or presence of metastatic focus of infection., Severe neutropenia (<500 cells / mm3) at the time of diagnosis of bacteremia, Pregnancy and lactation.

发起方