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Clinical Trials/NCT06659354
NCT06659354
Active, not recruiting
Not Applicable

Targeting Health and Resilience for Individuals With a Vulnerable Eating History (THRIVE)

Massachusetts General Hospital1 site in 1 country60 target enrollmentJune 6, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Eating Disorders
Sponsor
Massachusetts General Hospital
Enrollment
60
Locations
1
Primary Endpoint
Feasibility of recruitment
Status
Active, not recruiting
Last Updated
5 months ago

Overview

Brief Summary

The investigators aim to conduct a feasibility randomized controlled trial (RCT) of an eating disorder prevention program (The Body Project, adapted for pregnancy) versus a health education control among pregnant individuals with histories of an ED. The investigators will test the feasibility, implementation outcomes, and its preliminary effectiveness in reducing the risk of elevated disordered eating and body dissatisfaction during pregnancy and postpartum.

Detailed Description

The investigators aim to conduct a feasibility randomized controlled trial (RCT) of an eating disorder prevention program (The Body Project, adapted for pregnancy) versus a health education control among pregnant individuals with histories of an ED. The investigators will test the feasibility, implementation outcomes, and its preliminary effectiveness in reducing the risk of elevated disordered eating and body dissatisfaction during pregnancy and postpartum. The investigators will aim to recruit N=60 pregnant individuals (in their first or second trimester) with histories of an ED. Both the intervention and active control consist of 6, weekly, 1-hour group sessions (6-8 participants per group) delivered over Zoom. There are four assessment points: pre-intervention, post-intervention, 3 months postpartum, and 6 months postpartum. Participants will complete online surveys at each assessment point and a post-intervention exit interview (active intervention only).

Registry
clinicaltrials.gov
Start Date
June 6, 2024
End Date
April 1, 2026
Last Updated
5 months ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Rachel Vanderkruik

Associate Director of Research and Cognitive Behavioral Services

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

  • Within the first or second trimester of pregnancy at enrollment
  • 18 years or older
  • Able to provide informed consent
  • Endorse a self-reported history of an eating disorder or disordered eating behaviors
  • Are willing and able to comply with all group and study procedures
  • English fluency and literacy

Exclusion Criteria

  • A diagnosis of bipolar or psychotic disorder, active mania or psychosis or substance abuse, an active eating disorder (active eating disorder symptomology informed by the Screening, Brief Intervention, and Referral to Treatment for Eating Disorders (SBIRT-ED) tool and clinician discretion), being at immediate risk of self-harm
  • Do not have access to a device with a camera

Outcomes

Primary Outcomes

Feasibility of recruitment

Time Frame: 0 weeks

The investigators will consider the program feasible if the investigators meet recruitment targets (N=60).

Session attendance

Time Frame: 6 weeks

The investigators will assess what percentage of enrolled participants complete 4 or more sessions. The benchmark will be \> 50% of participants will complete 4 or more sessions.

Drop Out

Time Frame: 6 weeks

The investigators will assess what percentage of enrolled participants complete post-test assessments. The benchmark will be \> 50% of participants will complete the post-test surveys and interviews.

Client satisfaction questionnaire (CSQ-8)

Time Frame: 6 weeks

Assesses participants' satisfaction with the intervention. Scores range from 8 to 32 with higher scores indicating greater satisfaction. The benchmark will be that at least 70% of participants will have scores over and above the midpoint in both the PBP and PHE groups.

Credibility and Expectancy Questionnaire (CEQ)

Time Frame: 0 weeks

Assesses participants' perceptions that the treatment will work after learning about the study. The first three items measure credibility, and the latter three items measure expectancy. It is scored on a scale of 3-27 with higher scores indicating greater confidence in the treatment. The benchmark will be that at least 70% of participants will have scores over and above the midpoint in both the PBP and PHE groups.

Feasibility of data collection

Time Frame: Through the study completion, approximately 1 year depend on gestational at enrollment

E.g.: The investigators will assess the feasibility of quantitative measures with the benchmark of no questionnaires fully missing in \>25% of participants

Adapted Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM), & Feasibility of Intervention Measure

Time Frame: 6 weeks

Assesses acceptability, appropriateness, and feasibility of the intervention and Facilitators and Barriers to Participating. Acceptability, appropriateness, and feasibility subscales each consist of 4 items ranging from 1-5. Scores can be calculated by averaging the 4 items and range from 1-5. Higher scores indicate greater acceptability, appropriateness, and feasibility. The benchmark will be that at least 70% of participants will have scores over and above the midpoint for these subscales in both the PBP and PHE groups. Facilitators and Barriers to participating are open-ended questions and will be assessed with qualitative analyses.

Facilitator Adherence to Sessions

Time Frame: Through the study completion, approximately 1 year depend on gestational at enrollment

The investigators will assess the percentage of sessions with ≥75% adherence. The benchmark will be ≥70% of sessions will have ≥75% adherence (checklist and audio recordings); 20% of sessions rated.

Participant Adherence to Homework

Time Frame: 6 weeks

The investigators will assess the percentage of participants that complete (i.e., upload/submit) ≥75% of the homework assignments. The benchmark will be ≥70% of participants will complete ≥75% of the homework assignments.

Secondary Outcomes

  • Thin Ideal Internalization Scale(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • The Satisfaction and Dissatisfaction with Body Parts Scale(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Prenatal Eating Behaviors Screening (PEBS)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Eating Disorder Diagnostic Scale (EDDS)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Edinburgh Postnatal Depression Scale (EPDS)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Dutch Restrained Eating Scale(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Intuitive Eating Scale-3 (IES-3)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Body Image in Pregnancy Scale (BIPS)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Eating Disorder Examination Questionnaire (EDEQ)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Generalized Anxiety Disorder Assessment (GAD-7)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Multidimensional Scale of Perceived Social Support (MSPSS)(0 weeks, 6 weeks, 3 months pp, 6 months pp)
  • Participant Feedback(6 weeks)
  • Neonatal Outcomes(3 months pp)
  • Facilitator Feedback(Through the intervention program completion, approximately 1 year)

Study Sites (1)

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