The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine for Upper Limb Surgery: a Prospective Randomized Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- sensorial and motor block duration
研究概览
简要总结
The purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration, postoperative analgesia duration, postoperative pain intensity
详细描述
Brachial plexus blocks are frequently used in surgical procedures involving the upper limb because they facilitate surgical anaesthesia, muscle relaxation and post-operative analgesics.
Various drugs are used to supplement local anaesthetics during brachial plexus block. Many studies in the literature show that clonidine, which is an alpha-2 agonist, prolongs the length of anesthesia and post-operative analgesia.4,5 However, clonidine's side effects-such as hypotension, bradycardia and sedation can limit its use.
There are no studies comparing different clonidine concentrations on the axillary brachial block, so the hypothesis of the present study was that different clonidine concentrations and LA volumes may influence the anaesthesia and analgesia quality on this type of regional block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •both genders,
- •over 18 years old,
- •American Society of Anesthesiologists (ASA) 1 to 3
排除标准
- •patients with chronic use of analgesics and non-steroidal anti-inflammatories drugs,
- •pregnant,
- •with infection at the puncture site,
- •coagulopathies or intolerance to drugs used in the study
研究组 & 干预措施
low clonidine concentration
clonidine concentration 1 ml on 40 ml of lidocaine 1.5% for upper brachial plexus
干预措施: low clonidine concentration (Drug)
lidocaine 20 ml 1,5%
lidocaine 20 ml 1,5% without clonidine for axillary brachial plexus block for upper limb surgery
干预措施: Lidocaine (Drug)
high clonidine concentration
clonidine concentration 150 mcg on 20 ml of lidocaine 1,5% for upper brachial plexus
干预措施: high Clonidine concentration (Drug)
40 ml lidocaine 1,5%
40 ml of lidocaine 1,5% without clonidine for upper brachial plexus
干预措施: Lidocaine 40 ml (Drug)
结局指标
主要结局
sensorial and motor block duration
时间窗: 24 hours after surgery
to compare two concentrations of clonidine on different volumes of lidocaine, in terms of sensorial and motor block duration
次要结局
- adverse effects of additive clonidine on axillary brachial plexus block in upper limb surgery(24 hours after surgery)
- postoperative analgesia duration(24 hours)
- sensorial and motor block onset time(24 hours)
- postoperative pain intensity(24 hours)
研究者
Alexandra Rezende Assad
Assad AR
Universidade Federal do Rio de Janeiro