Dietary approaches for treatment of the metabolic syndrome in overweight and obese women.

Not Applicable

Completed

• Conditions: Metabolic syndrome in overweight and obese women; Diabetes prevention in overweight and obese women; Insulin resistance in overweight and obese women; Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12610000852055
• Lead Sponsor: Professor Jim Mann

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-10-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

Overweight (body mass index (BMI)> 27kg/m^2). Weight stable over last 3 months. Prepared to undergo dietary intervention and eat substantial amounts of dietary fibre including wholegrains, legumes and pulses.

Exclusion Criteria

No diabetes, psychiatric illness, drug or alcohol dependence that would affect ability to adhere to the dietary guidelines. No history of an eating disorder or renal or hepatic failure. Not on lipid lowering medications or medications known to affect metabolism. Not pregnant, lactating or planning to become pregnant in the next 8 weeks.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Body weight (determined using electronic calibrated scales) and waist circumference (determined using a tape measure at the midpoint between the anterior superior iliac spine of the hip and bottom of the ribcage).[Baseline and week 8];Total body fat, total lean mass and trunkal fat mass (measured by Dual Energy X-ray Anthropometry).[Baseline and week 8.];Blood lipids, blood glucose, blood pressure and insulin sensitivity as measured by the Homeostasis Model Assessment for Insulin Resistance and by the McAuley Index.[Baseline and week 8.]

Secondary Outcome Measures

Name	Time	Method
Fasting plasma insulin, C-reactive protein, adiponectin, tumor necrosis factor alpha (TNF-alpha), plasminogen activator inhibitor -1 (PAI-1), interleukins 6, 8 and 18, grehlin, magnesium and serum uric acid.[Baseline and week 8.]