Fibre, protein and insulin resistance diet study
Phase 1
Completed
- Conditions
- Insulin resistance in healthy overweight women.Diabetes prevention in healthy overweight women.Metabolic syndrome in healthy overweight women.Metabolic and Endocrine - DiabetesDiet and Nutrition - Obesity
- Registration Number
- ACTRN12607000154404
- Lead Sponsor
- Dr Kirsten McAuley
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 72
Inclusion Criteria
Overweight; BMI = 27 kg/m2 and weight < 120 kg or BMI >23 kg/m2 and a direct family history of type 2 diabetes.Normal or impaired glucose tolerance.Weight stable over last 3 months and willing to maintain weight initially.Prepared to undergo dietary intervention and eat substantial amounts of dietary fibre including wholegrains, legumes and pulses.
Exclusion Criteria
No diabetes, history of cardiovascular disease, or renal or hepatic failure.Not suffering from any other major medical condition.No psychiatric illness, drug or alcohol dependence that would affect ability to adhere to the dietary guidelines.Not pregnant or lactating.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insulin resistance measured by both a new dynamic method and Homeostasis Model Assessment for Insulin Resistance (HOMA-IR)[At baseline, 4 weeks and 10 weeks.]
- Secondary Outcome Measures
Name Time Method Weight[At baseline, 4 weeks and 10 weeks.];Fasting plasma lipids, glucose, insulin, C-Reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), adiponectin, interleukin 6 (IL6), interleukin 18 (IL18), tumour necrosis factor alpha and grehlin; and percentage body fat mass and lean mass, and waist and hip circumference.[At baseline and 10 weeks]