Investigating the Effect of MIND Diet with Restricted Calories and Probiotic Supplement on Fertility in Overweight and Obese Males

Phase 3

Recruiting

Conditions: Obesity and overweight.
Obesity due to excess calories
E66.0

Registration Number: IRCT20240313061277N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Male

Target Recruitment: 84

Inclusion Criteria

Having informed consent
Married adult men
Ages 20-45 years
Overweight and obese men with a body mass index greater than 25
Not using probiotic supplements in the last 3 months

Exclusion Criteria

Suffering from Azoospermia
Having a Varicocele
Suffering from Cryptorchidism
Suffering from Microorchidism
History of Vasectomy
Men taking drugs that harm spermatogenesis such as sulfasalazine
Men with tobacco, alcohol or drug use
Getting infections and anatomical abnormalities of the genital system
Suffering from cancer and chronic diseases

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Semen parameters (concentration, motility, percentage of live sperm, morphology, sperm DNA fragmentation index). Timepoint: Before and 3 months after the intervention. Method of measurement: Light microscope with 1000x magnification will be used to calculate movement, number of live sperm and morphology.;Serum levels of androgens (total testosterone, free testosterone, dihydroepiandrosterone). Timepoint: Before and 3 months after the intervention. Method of measurement: by ELISA method by monobind kits.;Sexual performance score. Timepoint: Before and 3 months after the intervention. Method of measurement: Male sexual performance questionnaire.;Sex life quality score. Timepoint: Before and 3 months after the intervention. Method of measurement: Men's Sexual Quality of Life Questionnaire: SQOL-M.

Secondary Outcome Measures