Hyperalgesia and NMDA Receptor Antagonist

Not Applicable

• Conditions: Pain
• Interventions: Drug: ketamine; Drug: Magnesium Sulfate

• Registration Number: NCT02087202
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

NMDA receptor is administered and postoperative remote hyperalgesia is investigated.

Detailed Description

NMDA receptor is adminstered and postoperative tertiary hyperalgesia is investigated.

QST and pain measures for remote hyperalgesia are compared between control and magnesium or ketamine group.

Study Timeline

• Status Verified: 2014-03
• Study Start: 2014-03
• Study First Submitted: 2014-03-12
• Study First Submitted QC: 2014-03-12
• Last Update Submitted: 2014-03-12
• Study First Posted: 2014-03-14
• Last Update Posted: 2014-03-14
• Primary Completion: 2014-07
• Study Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• ASA1-2

Exclusion Criteria

• contraindication to the study drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ketamine	ketamine	ketamine is administered to those patients undergoing stated TKA and other operations.
magnesium	Magnesium Sulfate	magnesium is added perioperatively to those patients undergoing staged total knee arthroplasty and other surgeries.

Primary Outcome Measures

Name	Time	Method
pain	until 1 month from the end of the operation	pain (QST and pain measures )until 1 month from the end of the operation