MedPath

Magnesium sulfate

Generic Name
Magnesium sulfate
Brand Names
Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
Drug Type
Small Molecule
Chemical Formula
MgO4S
CAS Number
7487-88-9
Unique Ingredient Identifier
ML30MJ2U7I

Overview

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Background

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.

Associated Conditions

  • Constipation
  • Convulsions
  • Hypomagnesemia
  • Torsades de Pointes
  • Barium poisoning
  • Severe Exacerbation of asthma

FDA Approved Products

Magnesium Sulfate
Manufacturer:Cantrell Drug Company
Route:INTRAVENOUS
Strength:20 g in 250 mL
Approved: 2012/08/24
NDC:52533-107
SODIUM SULFATE, POTASSIUM SULFATE, MAGNESIUM SULFATE
Manufacturer:Novel Laboratories, Inc.
Route:ORAL
Strength:1.6 g in 177 mL
Approved: 2017/12/04
NDC:40032-700
SODIUM SULFATE, POTASSIUM SULFATE, MAGNESIUM SULFATE
Manufacturer:Lupin Pharmaceuticals, Inc.
Route:ORAL
Strength:1.6 g in 177 mL
Approved: 2023/12/20
NDC:43386-700
Magnesium Sulfate
Manufacturer:Cantrell Drug Company
Route:INTRAVENOUS
Strength:20 g in 500 mL
Approved: 2012/08/24
NDC:52533-099
Elliotts B
Manufacturer:QOL Medical, LLC
Route:INTRATHECAL
Strength:3 mg in 10 mL
Approved: 2012/03/20
NDC:67871-007

Singapore Approved Products

DBL Magnesium Sulfate Concentrated Injection 49.3%
Manufacturer:Siegfried Hameln GmbH
Form:INJECTION
Strength:2.47 g/5 ml
Online:Yes
Approved: 1991/05/21
Approval:SIN05860P
SMOFKABIVEN EXTRA NITROGEN EMULSION FOR INFUSION
Manufacturer:Fresenius Kabi AB, Site Uppsala
Form:INJECTION, EMULSION
Strength:0.61g/1000ml
Online:Yes
Approved: 2021/03/24
Approval:SIN16135P
LEMON SWEET PURGATIVE SYRUP
Manufacturer:SYARIKAT WEN KEN DRUG SDN BHD
Form:SYRUP
Strength:35.4%
Online:Yes
Approved: 1989/05/09
Approval:SIN02748P

Drug Development Updates

Stay informed with timely notifications on clinical trials and research advancements.

© Copyright 2025. All Rights Reserved by MedPath