frailty and muscular paralysis association after surgery under general anaesthesia
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/08/044874
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age above 60 years
2.Undergoing surgery of duration from 1-3 hours
3.Can give informed consent themselves
Exclusion Criteria
1.Significant kidney disease (stage 4 kidney disease or higher).
2.Significant liver disease (Child-Pugh B or C class).
3.Allergic to neostigmine or sugammadex.
4.History of a neuromuscular disorder.
5.History of chronic obstructive pulmonary disease.
6.Pregnancy or nursing women.
7.Refusal to participate.
8.Arrhythmic disease or taking anti-arrhythmic drugs.
9.Inability to extubate at the end of surgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the ratio of the handgrip strength at TOF count of 0.9 to the TFIO at baselineTimepoint: 60 MINUTES
- Secondary Outcome Measures
Name Time Method (1) the ratio of the handgrip strength, parasternal intercostal muscle, diaphragm excursion at the time of TOF 0.9, cTOFr 0.9 and 30 min after PACU admission to baseline, respectively; ( <br/ ><br>2) the recovery time from TOFr 0.9 to TOFr 0.95 and to unity, respectively. <br/ ><br>Timepoint: from pre induction to 30 minutes after surgery