Impact of Metallic Stent Insertion for Obstructing Colorectal Cancer on Circulating Tumor Cell Dissemination
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- The University of Hong Kong
- Enrollment
- 40
- Primary Endpoint
- Changes of circulating tumor cell level before and after colonic stenting for patients with obstructive colorectal cancer
Study Overview
Brief Summary
This study aims to examine the hypothesis of tumor cell dissemination after colonic stenting for obstructing colorectal cancer by measuring the level of plasma circulating tumor cell before and after the procedure of successful colonic stenting in patients.
Detailed Description
- Patient recruitment:
Patients will be recruited from the Division of Colorectal Surgery, Department of Surgery, the University of Hong Kong, over a 12 - 18 months period. Our institution is a tertiary referral center for colorectal cancer patients in Hong Kong. Informed consent will be obtained from the patients after the inclusion criteria are met.
The study plans to recruit 25 patients in the colonic stenting group to compare with 15 patients in the control group.
Inclusion criteria:
Colonic stenting group
- Patients with obstructive colorectal cancer that requires colonic stenting as treatment
- Age > 18 years and is able to give informed consent
- Informed consent for blood collection obtained
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Colonic stenting group
- •Patients with obstructive colorectal cancer that requires colonic stenting as treatment
- •Age > 18 years and is able to give informed consent
- •Informed consent for blood collection obtained
- •Control group
- •Patients with colorectal cancer who have colonoscopy without stenting
- •Age > 18 years and is able to give informed consent
- •Informed consent for blood collection obtained
Exclusion Criteria
- •Patients who refuse or who is unable to give informed consent on blood taking for the study.
Outcomes
Primary Outcomes
Changes of circulating tumor cell level before and after colonic stenting for patients with obstructive colorectal cancer
Time Frame: Before and first 3 days after procedure
The patients' peripheral blood will be collected before and on first 3 days after the procedure.
Secondary Outcomes
No secondary outcomes reported