Impact of Metallic Stent Insertion for Obstructing Colorectal Cancer on Circulating Tumor Cell Dissemination
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Changes of circulating tumor cell level before and after colonic stenting for patients with obstructive colorectal cancer
研究概览
简要总结
This study aims to examine the hypothesis of tumor cell dissemination after colonic stenting for obstructing colorectal cancer by measuring the level of plasma circulating tumor cell before and after the procedure of successful colonic stenting in patients.
详细描述
- Patient recruitment:
Patients will be recruited from the Division of Colorectal Surgery, Department of Surgery, the University of Hong Kong, over a 12 - 18 months period. Our institution is a tertiary referral center for colorectal cancer patients in Hong Kong. Informed consent will be obtained from the patients after the inclusion criteria are met.
The study plans to recruit 25 patients in the colonic stenting group to compare with 15 patients in the control group.
Inclusion criteria:
Colonic stenting group
- Patients with obstructive colorectal cancer that requires colonic stenting as treatment
- Age > 18 years and is able to give informed consent
- Informed consent for blood collection obtained
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colonic stenting group
- •Patients with obstructive colorectal cancer that requires colonic stenting as treatment
- •Age > 18 years and is able to give informed consent
- •Informed consent for blood collection obtained
- •Control group
- •Patients with colorectal cancer who have colonoscopy without stenting
- •Age > 18 years and is able to give informed consent
- •Informed consent for blood collection obtained
排除标准
- •Patients who refuse or who is unable to give informed consent on blood taking for the study.
结局指标
主要结局
Changes of circulating tumor cell level before and after colonic stenting for patients with obstructive colorectal cancer
时间窗: Before and first 3 days after procedure
The patients' peripheral blood will be collected before and on first 3 days after the procedure.
次要结局
未报告次要终点