Breakfast for Female Adolescent - NewStart

Not Applicable

Terminated

Interventions: Dietary Supplement: Breakfast with high protein dairy
Other: Exercise training
Other: Skipping breakfast

Brief Summary: Investigators will test the long-term health effects of eating a dairy-based protein-rich breakfast and/or performing regular physical training for 12 weeks in 100 previous 'breakfast skipping' young overweight women (2 x 2 factorial design). Measurements of body composition, physical fitness, metabolic health parameters, faeces (microbiota activity and composition), satiety and daily energy intake will be collected.

Detailed Description: The study is a 2×2-factorial randomized controlled trial with 4 study arms. The subjects will be randomly allocated to skip breakfast or eat high-protein yoghurt products (300g/day) and to either exercise 3x per week or maintain habitual physical activity for 12 weeks. Measurements and biological sampling will be performed at baseline and at the end of the intervention period.

The primary outcome will be fat mass and fat free mass. The investigators will also measure effects on weigth, waiste, health-related blood paramenters, muscle function, metabolites in urine and blood, and gut microflora and pH.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
High protein breakfast and maintain habitual physical activity	Skipping breakfast	Subject will consume a high protein dairy breakfast (300 g high protein yoghurt (skyr)) and maintain habitual physical activity.
High protein breakfast and maintain habitual physical activity	Breakfast with high protein dairy	Subject will consume a high protein dairy breakfast (300 g high protein yoghurt (skyr)) and maintain habitual physical activity.
Skipping breakfast and exercising three times per week	Exercise training	Subject will skip breakfast and participate in organized exercise-training three times per week (and maintain habitual physical activity)
High protein breakfast and exercising three times per week	Exercise training	Subject will consume a high protein dairy breakfast (300 g high protein yoghurt (skyr)) and and participate in organized exercise-training three times per week (and maintain habitual physical activity)
Skipping breakfast and maintain habitual physical activity	Skipping breakfast	Subject will skip breakfast and maintain habitual physical activity.
High protein breakfast and exercising three times per week	Breakfast with high protein dairy	Subject will consume a high protein dairy breakfast (300 g high protein yoghurt (skyr)) and and participate in organized exercise-training three times per week (and maintain habitual physical activity)

Primary Outcome Measures

Name	Time	Method
Body composition (DXA scan) 1	12 weeks	Fat mass in grams
Body composition (DXA scan) 2	12 weeks	Fat free mass in grams

Secondary Outcome Measures

Name	Time	Method
Height	12 weeks	Body hight (m)
Feaces pH	12 weeks	by pH determination of faeces
Blood metabolites	12 weeks	by metabolomics
LDL	12 weeks	Blood sample measurement of LDL
Fitness	12 weeks	Aastrand bike test
BMI	12 weeks	weight measurement in kg, height in meters
HbA1c	12 weeks	Blood sample measurement of HbA1c
HDL	12 weeks	Blood sample measurement of HDL
Muscle strength	12 weeks	grib strength (kg)
maximal jump height	12 weeks	maximal jump height (cm)
Urine metabolites	12 weeks	by metabolomics
Health related blood parameter 1	12 weeks	blood sample measurement of fasting glucose
Health related blood parameter 2	12 weeks	Blood sample measurement of fasting insulin
Health related parameter	12 weeks	Oral glucose tolerance test measured as the area under the curve
Food log	12 weeks	4-day food log (energy in KJ)
Gut microflora	12 weeks	by bacterial determination of faeces
weight	12 weeks	Body weight (kg)

Locations (1): Aarhus University, Department for Public Health, Section for Sport Science
🇩🇰
Aarhus, Denmark