Impact of Serum Progesterone Levels on the Day of Fresh and Frozen Embryo Transfer on the Ongoing Pregnancy Rates.

Completed

• Conditions: Infertility
• Interventions: Other: serum progesterone measurement

• Registration Number: NCT04839627
• Lead Sponsor: Hospital St. Joseph, Marseille, France

Brief Summary

Serum progesterone levels prepare the endometrium for implantation and play an important role during embryo transfer (ET). In clinical practice, luteal phase support progesterone supplementation is systematically offered to all women undergoing medically assisted procreation (AMP), independently of ET conditions (fresh and frozen).

The investigators propose to perform a prospective cross-sectional single-center cohort study to measure progesterone levels on the day of the ET on all AMP cycles and to compare these levels between active pregnancies and ET unsuccessful cycles. They will determine progesterone threshold levels corresponding to successful attempts in all ET strategies (fresh and frozen) as well as clinical and biological risk factors leading to luteal phase deficiency during ET. They could therefore individualize progesterone supplementation according to patient's needs.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-30
• Study First Submitted QC: 2021-04-06
• Study First Posted: 2021-04-09
• Study Start: 2021-06-16
• Primary Completion: 2023-06-01
• Study Completion: 2023-06-01
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-28
• Last Update Posted: 2023-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 250

Inclusion Criteria

• Age ≥ 18 years
• planned embryo transfer
• signed informed consent

Exclusion Criteria

• patients falsely included, major inclusion criteria not respected
• lack of social insurance
• refusal to participate in the research

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
serum progesterone measurement	serum progesterone measurement	-

Primary Outcome Measures

Name	Time	Method
Serum progesterone levels on the day of embryo transfer	During the procedure	µg/L

Secondary Outcome Measures

Name	Time	Method
pregnancy rate	1 month after procedure	Post-embryo transfer βHCG levels (UI/l).

Trial Locations

Locations (1)

Hopital Saint Joseph Marseille; 🇫🇷 Marseille, France