Predictive Value of Mid-luteal Serum Progesterone Levels in Egg Donation Cycles

Completed

• Conditions: Pregnancy
• Interventions: Other: Progesterone <25, >75; Other: Progesterone 25-75

• Registration Number: NCT02696694
• Lead Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA

Brief Summary

This study aims to investigate the impact of serum progesterone concentrations on the day of embryo transfer in egg donation cycles under hormonal replacement therapy. As secondary outcomes, the investigators will investigate if endometrial volume measured by three-dimensional (3D) ultrasound on the day of embryo transfer is related with progesterone levels and with chances of pregnancy.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02
• Study First Submitted: 2016-02-16
• Study First Submitted QC: 2016-02-25
• Study First Posted: 2016-03-02
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-28
• Last Update Posted: 2016-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 242

Inclusion Criteria

• Age<50 yo
• BMI < 30Kg/m2
• Hormonal replacement cycle
• Endometrial thickness >6.5 mm during proliferative phase
• Transfer of one or two blastocyst grade A-B according to ASEBIR

Exclusion Criteria

• Uterine pathology
• Cryptozoospermia
• Severe implantation failure (>6 GQ embryos transferred without success)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
<P25 ó >P75	Progesterone <25, >75	serum progesterone \<25 or \>75 percentile
P25-P75	Progesterone 25-75	serum progesterone between 25 and 75 percentile

Primary Outcome Measures

Name	Time	Method
mid-luteal serum progesterone level	one year

Secondary Outcome Measures

Name	Time	Method
endometrial volume	one year

Trial Locations

Locations (1)

IVI Valencia; 🇪🇸 Valencia, Spain