Progesterone Variation on the Final Day of Oocyte Maturation.

Completed

• Conditions: Progesterone Variation on Trigger Day; Circadian Rhythm; Controlled Ovarian Stimulation; Oocyte Donors
• Interventions: Diagnostic Test: Serum progesterone measure

• Registration Number: NCT03366025
• Lead Sponsor: Institut Universitari Dexeus

Brief Summary

The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retrieval before the ovulation triggering, by evaluating the daily variability of serum progesterone on the day of triggering in healthy women who perform a COS for oocyte donation, through multiple blood samplings.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-01
• Study First Submitted: 2017-11-28
• Study First Submitted QC: 2017-12-07
• Study First Posted: 2017-12-08
• Primary Completion: 2018-01-25
• Study Completion: 2018-01-25
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-03
• Last Update Posted: 2018-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 22

Inclusion Criteria

• Healthy oocyte donors according to spanish law for oocyte donation
• Controlled ovarian stimulation following a flexible antagonist protocol and stimulation with recombinant Follicular stimulating hormone.
• Informed consent signed

Exclusion Criteria

• Detection of luteinizing hormone surge before triggering

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Oocyte donors	Serum progesterone measure	Healthy oocyte donors undergoing ovarian stimulation with recombinant Follicular stimulating hormone

Primary Outcome Measures

Name	Time	Method
Progesterone variation among 4 different moments on the day of ovulation triggering	Progesterone will be measured 4 times on the day of ovulation triggering, each of them separated 4 hours from the previous one (total 4 samples within 12 hours): blood samples will be obtained at 8:00 am, 12:00 pm, 4:00 pm and 08:00 pm	Measurement of serum Progesterone (ng/ml) in each oocyte donor at 4 different times on the day of ovulation triggering: The primary outcome will be the variation among the 4 progesterone measurements for each patient within the fixed12 hours time (8:00am; 12:00pm; 4:00pm and 8:00pm).

Trial Locations

Locations (1)

Salud de la Mujer Dexeus; 🇪🇸 Barcelona, Spain