Comparaison of 3 Protocols of Ocytocin Administration in Cesarean Section
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- uterine tone
研究概览
简要总结
This study aimed to compare 3 doses of ocytocin in bolus injection and contnious perfusion during C section. these doses determined by: high, intermediate and low doses, were administred to parturients during elective or urgent C section under spinal anesthesia
详细描述
This study aimed to compare 3 doses of ocytocin in bolus injection and contnious perfusion during C section. these doses determined by: high, intermediate and low doses, were administred to parturients during elective or urgent C section under spinal anesthesia.
The aim was to determine the lowest efficient dose to prevent post partum hemorrage and with the lowest incidence of maternal side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
盲法说明
pre filled syringues of ocytocin were given to the care provider who didn't know the exact amount of ocytocin bolus and continious infusion
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All adult patients scheduled for C section under spinal anesthesia, monofoetal pregnancy, full term
排除标准
- •necessity of general anesthesia
- •non conscent
研究组 & 干预措施
High doses
the patients of this group recieved conventionnal doses of ocytocin after foetal extraction in C section: 5IU in bolus followed by 15IU in continuous infusion
干预措施: Ocytocin (Drug)
Intermediate doses
the patients of this group recieved after foetal extraction in C section: 2IU in bolus followed by 10IU in continuous infusion
干预措施: Ocytocin (Drug)
Low doses
the patients of this group recieved after foetal extraction in C section: 2IU in bolus followed by 5 IU in continuous infusion
干预措施: Ocytocin (Drug)
结局指标
主要结局
uterine tone
时间窗: 10 minutes
uterine tone juged by the obstetrician
次要结局
- hemoglobin rate(30 minutes after C section)
- side effects of Ocytocin(up to 30 minutes after C section)
- Additive boluses of Ocytocin(30 minutes after C section)
研究者
Mhamed Sami Mebazaa
Professor head of the anesthesia and intensive care department
Mongi Slim Hospital