Prognostic Value of the AMR Measured After PPCI in STEMI Patients

Active, not recruiting

• Conditions: ST Elevation Myocardial Infarction; Coronary Heart Disease

• Registration Number: NCT05653765
• Lead Sponsor: Henan Institute of Cardiovascular Epidemiology

Brief Summary

The goal of this observational study is to learn about in STEMI with Primary PCI Patients. The main questions it aims to answer are:

* To determine the value of AMR in predicting the long-term clinical prognosis of patients with STEMI after PPCI, and to find the best cut-off value.

* Analyze the factors of PPCI affecting AMR and explore the effective measures of PPCI microcirculation protection.

Radiographic images of STEMI receiving primary PCI treatment in several chest pain centers in China will be included. The last image of the infarct-related vessel will be used as a target to calculate its AMR. The relationship between AMR and long-term clinical prognosis was analyzed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-04
• Study First Submitted QC: 2022-12-14
• Study First Posted: 2022-12-16
• Study Start: 2022-12-20
• Primary Completion: 2023-12-20
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-12
• Last Update Posted: 2025-03-17
• Study Completion: 2025-03-20

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 2663

Inclusion Criteria

• Aged 18 or older
• Type 1 myocardial infarction
• Receive PPCI

Exclusion Criteria

• Failed to identify culprit vessels.
• Structural heart disease with moderate to severe aortic valve or mitral regurgitation and or stenosis that may affect cardiac function
• Dialysis patients with severe renal insufficiency
• Severe and uncontrollable arrhythmia
• Complicated with dilated cardiomyopathy
• Unable to tolerate dual antiplatelet therapy
• Severe and uncontrollable anemia
• Hyperthyroidism
• TIMI blood flow 0-1 grade after PPCI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MACEs	12 months	cardiac death, hospitalization for heart failure, target vessel revascularization，non-fatal MI

Secondary Outcome Measures

Name	Time	Method
cardiac death	12 months	All cause deaths will be considered cardiac unless a definite noncardiac cause can be established.
hospitalization for heart failure	12 months	Hospitalization for heart failure was defined as admission because of new or deteriorating signs and symptoms of heart failure combined with the findings of noninvasive imaging or elevated B-type natriuretic peptide(BNP) and/or N-terminal pro-BNP concentration, and a discharge diagnosis of congestive heart failure.
target lesion revascularization	12 months	The following 3 conditions need to be met at the same time: 1. The new stenosis that developed within previously treated coronary segments and within 5 mm of their borders; 2. The new stenosis resulted in the vessel μQFR ≤ 0.80; 3. The patient subsequently underwent repeat PCI or coronary artery bypass grafting (CABG).
Repeated myocardial infarction	12 months	Repeated myocardial infarction

Trial Locations

Locations (5)

Shangqiu first people's Hospital; 🇨🇳 Shangqiu, Henan, China

Department of Cardiology, First Affiliated Hospital of Xinxiang Medical University; 🇨🇳 Xinxiang, Henan, China

Yongcheng Central Hospital; 🇨🇳 Yongcheng, Henan, China

Fuwai central China cardiovascular Hospital; 🇨🇳 Zhengzhou, Henan, China

Renji Hospital, School of Medicine, Shanghai Jiao Tong University,; 🇨🇳 Shanghai, Shanghai, China