Effects of Heating Transfusion on Brain Function
- Conditions
- Blood Transfusion
- Registration Number
- NCT01930305
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Brief Summary
To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.
- Detailed Description
Hypothermia is an effective therapeutic intervention to reduce hypoxic ischemia brain injury in animal experiments and in clinics.In a recent study, it has been shown that perioperative warming was associated with a higher incidence of cognitive dysfunction in elderly patients.Therefore, we hypothesised that perioperative heating transfusion have a side effect on brain function of surgical patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- adult patients scheduled for major surgery under general anesthesia and they probably need a blood transfusion during the procedure.
•Patients with a history of stroke, central nervous system disease , metabolic disturbance, psychiatric illness, hearing impairment, drug abuse or unwilling to participate in assessment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brain fuction during perioperative period Change from baseline at post-transfusion 15min, 30min, 1hour, 2hour, 3 hour, 6hour, 12hour, 24hour Brain function includes cerebral blood flow and cerebral oxygen saturation
- Secondary Outcome Measures
Name Time Method the cognitive performance and the score of postoperative quality recovery scales ( PQRS) Chang from baseline at 15min,40min,1day,3day and 7day postoperative lay
Trial Locations
- Locations (2)
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China