The effect of brain temperature on neuropsychological outcome following cardiopulmonary bypass

Completed

• Conditions: Cognitive deficits following cardiopulmonary bypass; Injury, Occupational Diseases, Poisoning; Brain injury

• Registration Number: ISRCTN59467488
• Lead Sponsor: niversity of Ottawa Heart Institute (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-06-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 334

Inclusion Criteria

Male or female 60 years or older undergoing coronary artery surgery utilising cardiopulmonary bypass.

Exclusion Criteria

1. Emergency surgery
2. Unable to undergo cognitive testing (visual or motor problems, unable to speak French or English)
3. Mini Mental State Examination (MMSE) less than 24 (dementia)
4. Patients undergoing other cardiac procedures in addition to coronary artery bypass graft (CABG) or reoperation
5. Patients with Parkinson's disease or a history of stroke
6. Age less than 60
7. Patients with renal insufficiency (creatinine 2 x normal) or hepatic insufficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of cognitive deficits at 5 - 7 days after surgery.

Secondary Outcome Measures

Name	Time	Method
1. Incidence of cerebral emboli during cardiopulmonary bypass (CPB) as measured by trans-cranial doppler<br>2. Quality of life at 3 months and the incidence of cognitive deficits at 3 months