Effect of Preoperative Nebulized Lidocaine on Postoperative Sore Throat After Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Changes in the incidence of postoperative sore throat
研究概览
简要总结
The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.
详细描述
Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization).
At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing video-assisted thoracic surgery requiring double lumen tube endotracheal intubation for one-lung ventilation
- •American Society of Anesthesiologists class 1,2 and 3
- •Ability to consent
排除标准
- •patients <18 years old
- •body mass index (BMI) <20 or >35 kg/m2
- •Mallampati grade 3 or 4
- •mouth opening < 3 cm
- •preexisting hoarseness or sore throat
- •coagulopathy
- •patient with upper respiratory tract infection
结局指标
主要结局
Changes in the incidence of postoperative sore throat
时间窗: 24 hours
Sore throat was assessed using a 0-100 mm visual analog scale (VAS), where a score of 0 represents no pain and a score of 100 reflects the worst pain imaginable.
次要结局
- Postoperative analgesic consumption(24 hours)
- Changes in heart rate(60 minutes)
- whether the hoarseness was present or not(24 hours)
- Changes in mean arterial pressure(60 minutes)
- Intraoperative opioid consumption(60 minutes)