Abnormal patterns of brain connectivity in major depression - APOBCIMD

niversiteit Maastricht0 个研究点目标入组 150 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Between 18 - 70 years old and able to give voluntary informed consent
•Diagnosis of unipolar depression. The diagnosis of depression will be made by the participants* treating psychiatrist/ psychologist and confirmed with the Structured Clinical Interview for DSM-IV (SCID-I).
•Severity of the depression: moderate to severe (BDI-II score >=20)
•Duration of the depression: longer than 2 months
•Are already receiving or will receive in the coming weeks treatment for depression;HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION
•Between 18 - 70 years old
•No current or history of major psychiatric illness
•A first-degree relative (i.e. father, mother, brother or sister) that has been diagnosed with unipolar depression. This diagnosis needs to be confirmed by the GP, psychologist or psychiatrist of the family member;HEALTHY CONTROLS
•Between 18 - 70 years old
•No current or history of major psychiatric illness
•No family history of major depression

•Meeting DSM-IV criteria for schizophrenia, schizo-affective disorder, bipolar disorder or an anxiety disorder as a primary diagnosis
•Meeting DSM-IV criteria for drug dependence as a primary diagnosis
•High suicidal risk (evaluated by the treating clinicians as part of standard therapy procedures)
•MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding
•Serious medical or neurological illness
•Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam
•HEALTHY PARTICIPANTS WITH FAMILY HISTORY OF DEPRESSION
•Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine
•MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding
•Serious medical or neurological illness
•Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam
•HEALTHY CONTROLS
•Meeting DSM-IV criteria for drug dependence, except caffeine or nicotine
•MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding.
•Serious medical or neurological illness
•Currently taking centrally acting medication which is known to have a large effect on brain functioning, such as benzodiazepam

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