Hemodynamics for Equi-MAC Anesthesia

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT03570164
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

Detailed Description

Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Study Timeline

• Study First Submitted: 2018-06-15
• Study First Submitted QC: 2018-06-15
• Study Start: 2018-06-18
• Study First Posted: 2018-06-26
• Primary Completion: 2018-11-13
• Study Completion: 2018-11-13
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-18
• Last Update Posted: 2019-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• patients aged between 19 and 65 yr
• patients with American Society of Anesthesiologists physical status classification I or II
• patients scheduled for elective arthroscopic knee surgery under general anesthesia
• patients obtaining written informed consent

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Exclusion Criteria

• patients with a history of any disease associated with the autonomic nervous system
• patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
• patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
• pregnant women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Anesthesia is maintained with sevoflurane.
Desflurane	Desflurane	Anesthesia is maintained with desflurane.

Primary Outcome Measures

Name	Time	Method
peripheral perfusion index	After a 30-min waiting period from the induction of anesthesia	peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC

Secondary Outcome Measures

Name	Time	Method
mean arterial pressure	After a 30-min waiting period from the induction of anesthesia	mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC
heart rate	After a 30-min waiting period from the induction of anesthesia	heart rate at a steady-state anesthesia of age-corrected 1.0 MAC

Trial Locations

Locations (1)

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of