Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- peripheral perfusion index
研究概览
简要总结
The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.
详细描述
Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged between 19 and 65 yr
- •patients with American Society of Anesthesiologists physical status classification I or II
- •patients scheduled for elective arthroscopic knee surgery under general anesthesia
- •patients obtaining written informed consent
排除标准
- •patients with a history of any disease associated with the autonomic nervous system
- •patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
- •patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia is maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia is maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
peripheral perfusion index
时间窗: After a 30-min waiting period from the induction of anesthesia
peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC
次要结局
- mean arterial pressure(After a 30-min waiting period from the induction of anesthesia)
- heart rate(After a 30-min waiting period from the induction of anesthesia)
研究者
Kyoung-Ho Ryu, MD
Assistant professor
Kangbuk Samsung Hospital