Neuropsychological Evaluation for Early Diagnosis of PSP

Completed

• Conditions: Cognitive Impairment; Progressive Supranuclear Palsy
• Interventions: Behavioral: Cognitive evaluation

• Registration Number: NCT03478124
• Lead Sponsor: Ospedale Generale Di Zona Moriggia-Pelascini

Brief Summary

The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.

Detailed Description

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.

Study Timeline

• Study Start: 2016-01-01
• Status Verified: 2018-03
• Primary Completion: 2018-03-01
• Study Completion: 2018-03-02
• Study First Submitted: 2018-03-20
• Study First Submitted QC: 2018-03-20
• Last Update Submitted: 2018-03-20
• Study First Posted: 2018-03-27
• Last Update Posted: 2018-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 112

Inclusion Criteria

• Patients fulfilling the criteria for idiopathic PD
• Patients fulfilling the criteria for PSP

Exclusion Criteria

• Any other neurodegenerative disorders or medical conditions different from PD / PSP

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PSP patients	Cognitive evaluation	Patients suffering from Progressive Supranuclear Palsy (PSP)
PD Patients	Cognitive evaluation	Patients suffering from Parkinson's disease (PD)

Primary Outcome Measures

Name	Time	Method
MoCA	1 year	Montreal Cognitive Assessment
RAVLT	1 year	Rey Auditory Verbal Learning Test
MMSE	1 year	Mini-Mental State Examination
WCST	1 year	Wisconsin Card Sorting Test
FAB	1 year	Frontal Assessment Battery
ST	1 year	Stroop Test
TMT-A and B	1 year	Trail Making Test Parts A \& B
VFT	1 year	Verbal fluency Test
ROCF copy and delayed recall	1 year	Rey-Osterrieth complex figure test copy and delayed recall

Secondary Outcome Measures

Name	Time	Method
TUG	1 year	Timed Up and Go Test
6MWT	1 year	6 Minute Walk Test
BBS	1 year	Berg Balance Scale